Medications for Chron’s Disease


Medications might be prescribed by your doctor for your Chron’s Disease.  There are several types of medications that can be used and you and your doctor might have to work as a team to figure out which one(s) will work for you.  Keep your doctor informed of any side effects you might have when starting a new medication.

Sulfasalazine is a drug that is often used at the beginning of treatment.  It works in 40% to 80% of patients treated in stopping the symptoms but often doesn’t keep the symptoms from coming back in Chron’s patients.  Sulfasalazine is a sulfa drug and should not be taken by people with an allergy to sulfa.

Mesalamineis used to minimize the number of stools you have and to help eliminate the bloody stools.  It is used in a suppository or enema and is effective on 45% to 55% of patients treated.  Patients have gone into remission using this drug. Using a suppository or enema directly applies the drug to the area rather than having the drug partially digest in your stomach.



Corticosteroids such as prednison, hydrocortisone, or Entocort might be prescribed.  These medications are given to help reduce the inflammation in the bowel.  Corticosteroids are usually given orally but, if the Chron’s is severe, can be given intravenously in a hospital.

Azathioprine and mercaptopurine are known to help people stay in remission after surgery.  They are also used to heal fistulas.  These medications could help patients stay off Corticosteroids.

Biologics are used in moderate to severe cases of Chron’s Disease.  They stop the production of protein that causes inflammation in the intestines. They have been shown in about 70% of people that use them to help keep them in remission. They are given in the treatment of fistulas as well as Chron’s Disease. They are given intravenously or in a shot.

Consult with your doctor and pharmacist on any medications that might be prescribed for your Chron’s Disease.  He or she will know how the medication works and whether or not it will interfere with anything else you are taking including vitamins and minerals. Your pharmacist, especially, will find any interactions with other things you take.

Medications for Chron’s Disease

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